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OCR was significantly blocked, and ATP production, basal respiration, and maximal respiration were significantly decreased after COM treatment compared to that in the control group

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Detailed molecular structure Comparison with native IGF-1 Native human IGF-1 is a 70-amino-acid peptide with three intramolecular disulfide bridges (Cys6-Cys48, Cys47-Cys52, Cys18-Cys61) stabilizing its folding into four domains (B, C, A, D) analogous to those of proinsulin